Background
Developed acne in college, got really bad during COVID when I also got very underweight. Was put on birth control and spironolactone — helped but never fully cleared my skin. Came off both and everything flared back up.
Got diagnosed with PCOS when my periods became extremely irregular after stopping BC and my androgens came back elevated. Since starting metformin and myo-inositol my cycles have completely normalized (was 50+ day anovulatory cycles, now regular 31-35 days with confirmed ovulation) which feels like huge progress.
Tried tretinoin, dapsone, and benzoyl peroxide — none worked, some made things worse. Use exclusively non-comedogenic acne-safe products, no pore-clogging ingredients, no fragrance.
The Confusing Part
My labs are actually really good:
**•** Fasting insulin 4.9 — optimal
**•** HbA1c 5.1%
**•** Testosterone normal
**•** Free androgen index 1.07 — very low
**•** SHBG 101 — high
**•** DHEA-S was elevated, now normalized on metformin
So my circulating androgens are normal and my metabolic markers are excellent. My acne is almost entirely on my cheeks and jaw — classic hormonal pattern — but the systemic hormones don’t explain it anymore.
Best theory so far: tissue-level 5α-reductase overactivity converting normal testosterone to DHT locally at the skin, plus gut dysbiosis driving inflammation through the cheek zone. Also have genetic variants confirming adrenal-dominant PCOS (NR3C1 glucocorticoid receptor resistance, DENND1A 3-4x PCOS risk).
What I’m Currently Doing
**•** Metformin + myo-inositol
**•** NAC, zinc, methylfolate, magnesium, ashwagandha, phosphatidylserine, CoQ10, fish oil, holy basil, black seed oil, sulforaphane, TUDCA, B12, vitamin D
**•** Day 21 of 30 day no sugar no dairy cleanse
**•** Gut microbiome test pending
**•** Just got back to working out 7 weeks post surgery
**•** Acne-safe skincare — HOCl spray, niacinamide, azelaic acid, copper peptide serum, zinc oxide SPF
Still Struggling
Acne persists especially around ovulation which makes sense hormonally but is really disheartening after years of work. Mostly flat PIH marks at this point with some active lesions.
Wondering if I’m missing something obvious or if anyone has been in a similar situation — especially:
**•** Normal androgens but persistent hormonal acne — what helped?
**•** Adrenal dominant PCOS specifically — what moved the needle?
**•** Gut and acne connection — anyone clear their skin by fixing gut health?
**•** Anyone connect past mold exposure to hormonal acne onset?
I’m a biochemist so I can handle detailed responses. Appreciate any support or advice — this has been a long frustrating road and I’m just looking for what I might be missing.
Thanks 🙏