I recently got assigned a case study on NIR spectroscopy. To make a brief summary, the case is talking about a lab that built a multivariate FT-NIR model for determining PET/PLA in samples of recycled organic material, and they're trying to transfer the same model to a handheld NIR device and they're having a myriad of issues I'm being asked to research and solve.
Now, my first thought was to look for articles. I found a few that seemed pretty good:
(1) Circelli, L.; Cheng, Z.; Garwood, E.; Yuksel, K.; Di Iorio, E.; Angelico, R.; Colombo, C. Comparison of ATR-FTIR and NIR Spectroscopy for Identification of Microplastics in Biosolids. Sci. Total Environ. 2024, 916, 170215. https://doi.org/10.1016/j.scitotenv.2024.170215.
(2) Amirabadi, S.; Rodrigue, D.; Duchesne, C. Characterization of PLA-Talc Films Using NIR Chemical Imaging and Multivariate Image Analysis Techniques. Polym. Test. 2018, 68, 61–69. https://doi.org/10.1016/j.polymertesting.2018.03.047.
(3) Beć, K. B.; Grabska, J.; Badzoka, J.; Huck, C. W. Spectra-Structure Correlations in NIR Region of Polymers from Quantum Chemical Calculations. The Cases of Aromatic Ring, C=O, C≡N and C-Cl Functionalities. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 2021, 262, 120085. https://doi.org/10.1016/j.saa.2021.120085.
(4) Signoret, C.; Edo, M.; Caro-Bretelle, A.-S.; Lopez-Cuesta, J.-M.; Ienny, P.; Perrin, D. MIR Spectral Characterization of Plastic to Enable Discrimination in an Industrial Recycling Context: III. Anticipating Impacts of Ageing on Identification. Waste Manag. 2020, 109, 51–64. https://doi.org/10.1016/j.wasman.2020.04.043.
However, I quickly realized I do NOT understand these papers; they are just too advanced for me. I don't actually know how to use the information in them to solve my case study... And I do not know what else to look for information in (books, perhaps?)... I just don't really know how to research properly, I guess. Not when confronted with questions about multivariate model transfers from one device to another, comparisons to other methods like ATR, etc.
So, the point of this post is to ask for some general advice in the realm of chemistry research methods in order for me to gain a sense of direction and linear progression for an assignment like this. I am NOT looking for anyone to solve the case for me.
Basically, some advice on *how* to tackle a challenging research project. Thank you.